PMID: 9428594Jan 15, 1998Paper

Synthesis of 11C-labeled desipramine and its metabolite 2-hydroxydesipramine: potential radiotracers for PET studies of the norepinephrine transporter

Nuclear Medicine and Biology
M E Van DortD Wieland

Abstract

The antidepressant desipramine (DMI) and its principal metabolite 2-hydroxydesipramine (HDMI) have been radiolabeled with 11C for PET studies. The normethyl precursors of DMI and HDMI were synthesized from iminodibenzyl in 35% and 11% overall yield, respectively. Direct methylation of the normethyl precursor with [11C]CH3I, followed by HPLC purification, provided [11C]DMI and [11C]HDMI in 18-30% and 15-23% decay-corrected radiochemical yields, respectively, in a 45 min synthesis time from end of bombardment. The specific activities of the two radiotracers were >1459 Ci/mmol at the end of synthesis. [11C]DMI and [11C]HDMI have potential utility as PET radiotracers for the norepinephrine transporter.

References

Sep 1, 1991·Trends in Pharmacological Sciences·U Trendelenburg
Jan 1, 1995·Journal of the American College of Cardiology·M BöhmE Erdmann
Sep 15, 1994·Annals of the New York Academy of Sciences·H Bönisch, M Brüss
Jun 1, 1996·Circulation Research·M UngererG Richardt
Dec 1, 1996·International Clinical Psychopharmacology·S L SternR F Suckow

❮ Previous
Next ❯

Citations

Dec 3, 2005·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Magnus SchouChrister Halldin
Nov 28, 2012·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·James T Thackeray, Frank M Bengel
Mar 24, 2000·European Journal of Pharmacology·A L MaliziaD J Nutt
Jun 29, 2004·Nuclear Medicine and Biology·Mei-Ping KungHank F Kung
Oct 26, 2005·Nuclear Medicine and Biology·Yu-Shin Ding, Joanna Fowler
Oct 19, 2004·Radiologic Clinics of North America·Chyng-Yann Shiue, Michael J Welch
Jul 25, 2007·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Maria Azzurra FilanninoFerruccio Fazio
Nov 3, 2004·CNS Spectrums·J McConathyM M Goodman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.