Synthesis of 1,2,4-triazole derivatives containing benzothiazoles as pharmacologically active molecule

Journal of Enzyme Inhibition and Medicinal Chemistry
Navin B Patel, Imran H Khan

Abstract

In attempt to make significant pharmacologically active molecule, we report here the synthesis and in vitro antimicrobial and antitubercular activity of various series of 3-(3-pyridyl)-5-(4-nitrophenyl)-4-(N-substituted-1,3-benzothiazol-2-amino)-4H-1,2,4-triazole. The antimicrobial activity of title compounds were examined against two Gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), two Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), and three fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus) using the broth microdilution method and antitubercular activity H(37)Rv using Lowenstein-Jensen agar method.

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Citations

Dec 3, 2014·European Journal of Medicinal Chemistry·Rangappa S KeriSrinivasa Budagumpi
Mar 14, 2019·Mini Reviews in Medicinal Chemistry·Ankit Jain, Poonam Piplani

Related Concepts

Benzothiazole
1,2,4-triazole, potassium salt
Antibiotics
Antibiotics, Antifungal
Dose-Response Relationship, Drug
Filamentous fungus
Fungus Drug Sensitivity Tests
Molecular Stereochemistry
Structure-Activity Relationship
Triazoles

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