Synthesis of 2-methyl 16-membered macrolide derived from tylosin

The Journal of Antibiotics
Yuichi TeruiAkira Kawashima

Abstract

To improve the metabolic stability of a 16-membered macrolide, 2-methylated derivatives of desmycosin were synthesized. Among these derivatives, 2beta-methyldesmycosin retained antibacterial activity and showed improved stability in rat serum compared to desmycosin.

References

Apr 1, 1983·The Journal of Antibiotics·A InoueK Shirahata
Jun 14, 2002·The Journal of Antibiotics·Lawrence C CreemerHerbert A Kirst
Apr 8, 2003·Current Topics in Medicinal Chemistry·Toshifumi AsakaHiroyuki Sugiyama

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Citations

Jul 22, 2010·Expert Opinion on Therapeutic Patents·Herbert A Kirst

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