Synthesis of 5-substituted 2'-deoxyuridine-5'- phosphonate analogues and evaluation of their antiviral activity

Nucleosides, Nucleotides & Nucleic Acids
Sara Van PoeckeSerge Van Calenbergh

Abstract

A small series of 5-(hetero)aryl-modified nucleoside phosphonates was synthesized via an 8-step procedure including a Wittig reaction and Suzuki-Miyaura coupling. An unanticipated anomerization during phosphonate deprotection allowed us to isolate both anomers of the 5-substituted 2'-deoxy-uridine phosphonates and assess their antiviral activity against a broad panel of viruses.

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Citations

Jul 2, 2014·Journal of the American Chemical Society·Kyle J SeamonJames T Stivers
May 15, 2015·Organic Letters·Anastasia P KadinaCharles E McKenna

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