PMID: 8472025Mar 1, 1993Paper

Synthesis of 6-[18F] and 4-[18F]fluoro-L-m-tyrosines via regioselective radiofluorodestannylation

Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
M NamavariJ R Barrio

Abstract

The regioselective radiofluorodestannylation of 6-trimethylstannyl-L-m-tyrosine derivative 6 with [18F]F2 and [18F]acetyl hypofluorite afforded, after acid hydrolysis, 6-[18F]fluoro-L-m-tyrosine (8a) in radiochemical yields of 23 and 17%, respectively. Similarly, 4-[18F]fluoro-L-m-tyrosine (13a) was synthesized in 11% radiochemical yield from the corresponding 4-trimethylstannyl-L-m-tyrosine derivative 11 using [18F]F2. The structural analyses of precursors (6,11), intermediates, and the final products (after 18F decay), were carried out by 1H, 13C, 19F, 119Sn-NMR and high resolution mass spectroscopy.

References

Aug 1, 1992·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·M NamavariJ R Barrio
Jun 15, 1990·Biochemical Pharmacology·W P MelegaJ R Barrio
Jan 1, 1990·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·A LuxenJ R Barrio
Jan 1, 1990·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·O T DeJesusE H Appelman
Jan 1, 1990·International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes·M PerlmutterJ R Barrio
Feb 1, 1987·Journal of Neurochemistry·P CummingE G McGeer
Sep 8, 1983·Nature·E S GarnettC Nahmias

❮ Previous
Next ❯

Citations

Apr 1, 1996·Nuclear Medicine and Biology·A BishopJ R Barrio
Jun 14, 2008·Cerebral Cortex·Susan M LandauWilliam J Jagust
Feb 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Roshan CoolsMark D'Esposito
Dec 20, 2008·NeuroImage·Massimo S FiandacaKrystof S Bankiewicz
Jun 4, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Catherine L GallagherSterling C Johnson
Sep 25, 2004·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Henry F VanBrocklinSimon Ametamey
Nov 16, 2001·Biochemical Pharmacology·R E YeeJ R Barrio
Mar 17, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D J DoudetJ E Holden
Jul 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J R BarrioM E Phelps
Jul 10, 2014·Nature Communications·Benjamin H RotsteinSteven H Liang
Nov 29, 2013·Journal of Labelled Compounds & Radiopharmaceuticals·Johannes Ermert, Heinz H Coenen
Mar 27, 2015·Journal of Labelled Compounds & Radiopharmaceuticals·Johnny Castillo MeleánHeinz H Coenen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes
M NamavariJ R Barrio
International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes
M M PerlmutterJ R Barrio
International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes
A LuxenJ R Barrio
Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine
A D RobertsR J Nickles
© 2021 Meta ULC. All rights reserved