Synthesis of a key Mycobacterium tuberculosis biosynthetic phosphoinositide intermediate

Bioorganic & Medicinal Chemistry Letters
K N JayaprakashBert Fraser-Reid


Regioselective mannosylations of a myoinositol acceptor diol are readily achieved by Lewis acid mediated iodinolysis of n-pentenyl ortho-esters. The procedure affords a psuedotrisaccharide to which the phosphoglyceryl and other lipid residues are added leading to the key biosynthetic intermediate of Mycobacterium species.


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