Synthesis of a mimic for the heterogeneous surface of core 2 sialoglycan-linked glycoprotein

Organic Letters
Yutaka TakanoYoshiaki Nakahara

Abstract

[structure: see text] An O-glycosylated peptide carrying two core 2 sialopentasaccharides of different glycoform was synthesized as a model of the heterogeneous surface of mucin glycoprotein. Solid-phase synthesis and the subsequent enzymatic sialylation gave two segments, which were coupled by selective thioester activation to produce the title compound.

References

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Citations

Apr 2, 2009·Journal of the American Chemical Society·Zhongping TanSamuel J Danishefsky
Aug 24, 2005·Bioscience, Biotechnology, and Biochemistry·Makoto MaemuraYoshiaki Nakahara
Oct 13, 2006·Bioscience, Biotechnology, and Biochemistry·Eriko TanakaYoshiaki Nakahara
May 18, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daisuke KobayashiHideharu Ishida
Dec 21, 2013·Journal of Peptide Science : an Official Publication of the European Peptide Society·Takaomi TakenouchiHironobu Hojo
Dec 22, 2009·Chemical Communications : Chem Comm·Richard J Payne, Chi-Huey Wong
Feb 6, 2007·Biopolymers·Hironobu Hojo, Yoshiaki Nakahara
May 6, 2006·Glycobiology·Therese BuskasGeert-Jan Boons
Jan 10, 2018·Chemistry : a European Journal·Naoki TakedaHironobu Hojo
Jul 27, 2017·Biochemistry·Patrick K ChaffeyZhongping Tan

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