Synthesis of a new family of 2-ethylidene-gamma-unsaturated delta-amino esters via microwave activated Stille coupling

Amino Acids
Gabriella Barozzino ConsiglioGianna Reginato

Abstract

A simple approach to a new family of enantiomerically enriched polyunsaturated t-Boc-protected-delta-amino esters is described, via microwave promoted Stille coupling of (Z)-methyl-2-bromobutenoate with stannylated allylamines. The reaction conditions are mild and selective and disclose a simple way to 1-substituted butenoates of defined geometry.

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