Synthesis of a novel polymer bile salts-(polyethylene glycol)2000-bile salts and its application to the liver-selective targeting of liposomal DDB

Drug Development and Industrial Pharmacy
Zhi-Peng ChenBao-Chang Cai

Abstract

The objective of this study was to achieve a sustained and targeted delivery of liposome to the liver, by modifying the phospholipid [phosphatidylcholine (PC)/cholesterol (10 : 1) liposomes with a novel polymer bile salts-(polyethylene glycol)(2000)-bile salts (BP(2)B). First, we generated a novel BP(2)B by N,N'-dicyclohexylcarbodiimide/4-dimethylaminopyridine esterification method and confirmed by Fourier transform infraredand (1) H-NMR spectra. Second, we prepared the BP(2)B-modified liposomes (BP(2)BL) that included BP(2)B, and the effect of the weight ratios of BP(2)B/PC on entrapment efficiency was investigated and BP(2)B/PC = 3% (w/w) was determined as the optimum ratio for the 4,4'-dimethoxy-5,6,5',6'-bi (methylenedioxy)-2,2'-bicarbomethoxybiphenyl liposomes. And then, the ability of the liver target of BP(2)BL was studied by calculating the targeted parameters. All the results revealed that the introduction of polyoxyethylene chains could control interactions of bile salt moieties on liposome surfaces with the receptor compared with traditional liposomes (CL), marking BP(2)BL as a suitable carrier for hepatic parenchymal cell-specific and sustained targeting. It was suggested that liposomes containing such novel BP(2)B ...Continue Reading

References

Jun 1, 1992·Antiviral Research·D K MeijerG Molema
Feb 1, 1987·Pharmaceutical Research·G Levy
Jun 1, 1985·Antimicrobial Agents and Chemotherapy·M KendeP G Canonico
Mar 1, 1972·Journal of Pharmaceutical Sciences·N B Shah, B B Sheth
Aug 1, 1965·Journal of Molecular Biology·A D BanghamJ C Watkins
Sep 1, 1996·European Journal of Clinical Investigation·W Kramer, G Wess
Feb 13, 2001·Journal of Pharmaceutical Sciences·S KawakamiM Hashida
Feb 22, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·H M RedheadL Illum
Mar 20, 2003·Archives of Pharmacal Research·Sang-Cheol ChiEun-Seok Park
Jul 5, 2003·Chemical & Pharmaceutical Bulletin·Kaname HashizakiNaotake Ogawa
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yasuyuki SadzukaTakashi Sonobe
Oct 16, 2003·International Journal of Pharmaceutics·Chittima ManagitMitsuru Hashida
Sep 2, 2004·The Journal of Pharmacology and Experimental Therapeutics·Mark D ErionDavid A Bullough
Jun 1, 2005·Chemistry and Physics of Lipids·Olga GarbuzenkoAba Priev
Jul 19, 2005·European Journal of Medicinal Chemistry·Xiuxiang QiJunbiao Chang
Mar 16, 2006·The Journal of Pharmacy and Pharmacology·S P VyasSanyog Jain
Jan 5, 2007·Biological & Pharmaceutical Bulletin·Ikumi Sugiyama, Yasuyuki Sadzuka
Apr 10, 2007·Bioorganic & Medicinal Chemistry Letters·Dimao WuYufen Zhao
Aug 19, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Zhi-Peng ChenYan-Yu Xiao
Apr 22, 2008·Progress in Lipid Research·Yvonne Lange, Theodore L Steck

❮ Previous
Next ❯

Citations

Apr 7, 2012·Expert Opinion on Drug Delivery·Zhipeng ChenBao-Chang Cai
Sep 19, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Abby J Schadock-HewittR Kenneth Marcus

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.