Synthesis of a ratiometric fluorescent peptide sensor for the highly selective detection of Cd2+

Bioorganic & Medicinal Chemistry Letters
Yan LiYangzhong Liu

Abstract

A novel ratiometric fluorescent peptidyl chemosensor (Dansyl-Cys-Pro-Gly-Cys-Trp-NH(2), D-P5) for metal ions detection has been synthesized via Fmoc solid-phase peptide synthesis. The chemosensor exhibited a high selectivity for Cd(2+) over other metal ions including competitive transition and Group I and II metal ions in neutral pH. The fluorescence emission intensity of D-P5 was significantly enhanced in the presence of Cd(2+) by fluorescent resonance energy transfer (FRET) and chelation enhanced fluorescence (CHEF) effects. The binding stoichiometry, detection limit, binding affinity, reversibility and pH sensitivity of the sensor for Cd(2+) were investigated.

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Citations

Sep 29, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Peng WangYu Tang
May 22, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Levente I SzekeresAttila Jancsó
Jan 25, 2014·Chemical Communications : Chem Comm·Qiaoling LiuMartin M F Choi
Jul 14, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Peng WangYu Tang
May 7, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Peng WangYu Tang
May 11, 2019·Luminescence : the Journal of Biological and Chemical Luminescence·Xuliang PangLianzhi Li
Sep 28, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jingchang YangDan Liu
Nov 21, 2020·Journal of Fluorescence·Shuaibing YuLianzhi Li
Dec 8, 2020·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Shuaibing YuLianzhi Li
Jun 12, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Shuaibing YuYing-Wu Lin

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