Synthesis of alpha 1-acid glycoprotein by the human prostate.

The Prostate
J Y DubéR R Tremblay

Abstract

In order better to define the extent of protein synthesis capacity of the human prostate, we have studied the translation of selected serum proteins using isolated poly(A)+ RNA preparations and the rabbit reticulocyte lysate system. The translation of alpha 1-acid glycoprotein could be conclusively demonstrated but there was no apparent translation of albumin and plasmatic transferrin. Labeled alpha 1-acid glycoprotein was identified by specific immunoprecipitation with a commercial anti alpha 1-acid glycoprotein antiserum and correct processing by canine pancreatic microsomal membranes. Furthermore, we have shown by the immunoperoxidase technique that alpha 1-acid glycoprotein was indeed localized mainly in prostatic epithelial cells in 2 out of 2 patients with benign prostatic hypertrophy and in 3 out of 11 patients with prostatic adenocarcinoma. The significance of the synthesis and secretion of alpha 1-acid glycoprotein by prostatic cell themselves is presently unknown. However, we think that it could represent an interesting subject to explore further in relation with prostatic inflammation.

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Citations

Apr 15, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ewa KratzIwona Katnik-Prastowska
Nov 4, 2000·Biochimica Et Biophysica Acta·T FournierD Porquet
Oct 16, 2012·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Mirosława Ferens-SieczkowskaEwa Maria Kratz
Nov 5, 2016·Cancer Biomarkers : Section a of Disease Markers·Rucksak RucksakenSomchai Pinlaor
Jan 29, 2020·Urologia·Gilmar Pereira SilvaDaniel Holanda Barroso
May 27, 2003·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Carolyn J M BestMichael R Emmert-Buck

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