Synthesis of amino-substituted indoles using the Bartoli reaction.

Organic & Biomolecular Chemistry
Laura WylieSwen Hoelder

Abstract

We report herein the concise preparation of a range of functionalised aminoindoles via a new application of the Bartoli reaction. Scope and limitations of the methodology have been extensively studied to reveal the importance of protecting groups and substitution patterns. The use of amino substituted nitroanilines for the Bartoli reaction is to our knowledge unprecedented. Our work thus represents a novel entry into substituted aminoindoles which are relevant building blocks for both the fine chemical and pharmaceutical industry.

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Citations

Jan 30, 2018·Chemistry : a European Journal·Marian RauserMeike Niggemann
Jan 23, 2015·Chemical Communications : Chem Comm·Vasudevan DhayalanPaul Knochel
Sep 13, 2014·Chemistry : a European Journal·Elier HernandoJuan C Carretero
Apr 11, 2014·Chemical Society Reviews·Giuseppe BartoliMonica Nardi
May 11, 2018·Organic & Biomolecular Chemistry·Yang GaoYanping Huo
Jul 3, 2013·Organic Letters·Takumi AbeMinoru Ishikura

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