Synthesis of an unusual branched-chain sugar, 5-C-methyl-L-idopyranose for SAR studies of pyranmycins: implication for the future design of aminoglycoside antibiotics

Bioorganic & Medicinal Chemistry Letters
Jinhua WangCheng-Wei Tom Chang

Abstract

The syntheses of a challenging branched-chain sugar and several L-sugars have been accomplished. Their application in studies of the antibacterial activity of pyranmycins is reported, which could provide new strategies for the future design of aminoglycoside antibiotics.

References

Jun 1, 1984·Antimicrobial Agents and Chemotherapy·B MalewiczE Borowski
Jun 19, 2001·Organic Letters·Y DingR H Griffey
Jun 27, 1997·The Journal of Organic Chemistry·Adam W. Mazur, George D. Hiler GD 2nd
Jun 18, 2002·Bioorganic & Medicinal Chemistry Letters·Hidehiko TanakaKazukiyo Kobayashi
Mar 6, 2003·Bioorganic & Medicinal Chemistry Letters·Do Hyun RyuRobert R Rando
Feb 14, 2004·Organic Letters·Chien-Hung ChouShang-Cheng Hung
Feb 28, 2004·The Journal of Organic Chemistry·Bryan ElchertCheng-Wei Tom Chang

❮ Previous
Next ❯

Citations

Feb 16, 2013·Carbohydrate Research·Zuzana Hricovíniová, Miloš Hricovíni
Jun 3, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wieslaw SzejaAleksandra Rusin
Feb 6, 2010·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Tam KhuuPeter J Ambrose
Aug 19, 2005·Expert Review of Anti-infective Therapy·André Bryskier
Apr 22, 2015·Chemical Reviews·Tobias Gylling FrihedChristian Marcus Pedersen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.