PMID: 3320563Jan 1, 1987Paper

Synthesis of antiprogestational steroids

Journal of Steroid Biochemistry
R Wiechert, G Neef

Abstract

The discovery of the first competitive progesterone antagonist RU 38,486 has initiated an intense search for more potent and more selective anti-progestins. Among several hundreds of compounds under preliminary investigation, biological characterization is most advanced for derivatives RU 38,486, ZK 98,734 and ZK 98,299. These compounds do not only differ in relative potency, but are clearly distinguished by their different behaviour in various animal models. Emphasis is laid on the synthetic problems associated with chemical operations in a sterically crowded environment as represented by structures RU 38,486 and ZK 98,299.

References


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Citations

Mar 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·H MichnaM F el Etreby
Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·H MichnaM R Schneider
Dec 13, 2002·The Journal of Steroid Biochemistry and Molecular Biology·Yuji TabataYasushi Kurata
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K DelabreE Milgrom
Jun 12, 1995·Annals of the New York Academy of Sciences·H MichnaY Nishino
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·H MiyamotoC Chang
Nov 1, 1993·Contraception·I M Spitz, C W Bardin
Mar 28, 2008·Expert Opinion on Investigational Drugs·Carsten MöllerWolfgang Schwede
Mar 1, 1994·Die Naturwissenschaften·M K Agarwal
Dec 5, 2020·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·Mariusz P KowalewskiAykut Gram
Apr 17, 1991·Biochimica Et Biophysica Acta·Z Zakula, V K Moudgil
Sep 1, 1988·Baillière's Clinical Obstetrics and Gynaecology·M Bygdeman, P F Van Look
Jan 11, 2001·Journal of Medicinal Chemistry·U FuhrmannK Chwalisz

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