journal cover

Synthesis of benzimidazole derivatives as potent β-glucuronidase inhibitors

Bioorganic Chemistry

Jun 16, 2015

Muhammad TahaMuhammad Ali

Abstract

Twenty five 4, 6-dichlorobenzimidazole derivatives (1-25) have been synthesized and evaluated against β-glucuronidase inhibitory activity. The compounds which actively inhibit β-glucuronidase activity have IC50 values ranging between 4.48 and 46.12 μM and showing better than standard d-...read more

Mentioned in this Paper

Study
Derivatives
Structure-Activity Relationship
Saccharic acid-1,4-lactone
Benzimidazole derivatives, antinematodal
Tertiary Protein Structure
Beta-glucuronidase
Plasma Protein Binding Capacity
Lactones
Evaluation
Paper Details
References
  • References9
  • Citations4
1
  • References9
  • Citations4
1

Similar Papers Found In These Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Related Papers

Bioorganic & Medicinal Chemistry

Novel 2,5-disubtituted-1,3,4-oxadiazoles with benzimidazole backbone: a new class of β-glucuronidase inhibitors and in silico studies

Bioorganic & Medicinal ChemistryMay 24, 2015
Nik Khairunissa Nik Abdullah ZawawiKhalid Mohammed Khan
Medicinal Chemistry

Synthesis and β-glucuronidase inhibitory potential of benzimidazole derivatives

Medicinal ChemistryApril 26, 2012
Khalid Mohammed KhanW Voelter
© 2020 Meta ULC. All rights reserved

Synthesis of benzimidazole derivatives as potent β-glucuronidase inhibitors

Bioorganic Chemistry

Jun 16, 2015

Muhammad TahaMuhammad Ali

PMID: 26073618

DOI: 10.1016/j.bio.2015.05.010

Abstract

Twenty five 4, 6-dichlorobenzimidazole derivatives (1-25) have been synthesized and evaluated against β-glucuronidase inhibitory activity. The compounds which actively inhibit β-glucuronidase activity have IC50 values ranging between 4.48 and 46.12 μM and showing better than standard d-...read more

Mentioned in this Paper

Study
Derivatives
Structure-Activity Relationship
Saccharic acid-1,4-lactone
Benzimidazole derivatives, antinematodal
Tertiary Protein Structure
Beta-glucuronidase
Plasma Protein Binding Capacity
Lactones
Evaluation

Similar Papers Found In These Feeds

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Related Papers

Bioorganic & Medicinal Chemistry

Novel 2,5-disubtituted-1,3,4-oxadiazoles with benzimidazole backbone: a new class of β-glucuronidase inhibitors and in silico studies

Bioorganic & Medicinal ChemistryMay 24, 2015
Nik Khairunissa Nik Abdullah ZawawiKhalid Mohammed Khan
Medicinal Chemistry

Synthesis and β-glucuronidase inhibitory potential of benzimidazole derivatives

Medicinal ChemistryApril 26, 2012
Khalid Mohammed KhanW Voelter
Paper Details
References
  • References9
  • Citations4
1
  • References9
  • Citations4
1
/papers/synthesis-of-benzimidazole-derivatives-as-potent--/26073618