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Synthesis of benzimidazole derivatives as potent β-glucuronidase inhibitors

Bioorganic Chemistry

Aug 1, 2015

Muhammad TahaMuhammad Sajjad Ali

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Abstract

Twenty five 4, 6-dichlorobenzimidazole derivatives (1-25) have been synthesized and evaluated against β-glucuronidase inhibitory activity. The compounds which actively inhibit β-glucuronidase activity have IC50 values ranging between 4.48 and 46.12 μM and showing better than standard d-...read more

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  • Synthesis of benzimidazole derivatives as potent β-glucuronidase inhibitors

    Bioorganic Chemistry

    Aug 1, 2015

    Muhammad TahaMuhammad Sajjad Ali

    PMID: 26073618

    DOI: 10.1016/j.bio.2015.05.010

    Abstract

    Twenty five 4, 6-dichlorobenzimidazole derivatives (1-25) have been synthesized and evaluated against β-glucuronidase inhibitory activity. The compounds which actively inhibit β-glucuronidase activity have IC50 values ranging between 4.48 and 46.12 μM and showing better than standard d-...read more

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