PMID: 6830857Apr 20, 1983Paper

Synthesis of biopterin from dihydroneopterin triphosphate by rat tissues

Biochimica Et Biophysica Acta
S YoshiokaM Akino


High performance liquid chromatography procedure for the analysis of pterins of biopterin synthesis from dihydroneopterin triphosphate via sepiapterin in rat tissues has been described. Sepiapterin-synthesizing enzyme 1, which catalyzes in the presence of Mg2+ the conversion of dihydroneopterin triphosphate to an intermediate designated compound X was assayed by determining pterin which is formed from compound X under acidic conditions. Sepiapterin- and biopterin-synthesizing activity were also assayed by determining sepiapterin and biopterin, respectively. Analytical results revealed the presence of these activities in most rat tissues examined and high levels were found in kidney, pineal gland and liver. Activities were also detectable in peripheral erythrocytes.


Dec 29, 1974·Biochimica Et Biophysica Acta·S KatohS Yamada
Oct 1, 1968·Archives of Biochemistry and Biophysics·T Fukushima, M Akino
Aug 31, 1981·FEBS Letters·M HäusermannH C Curtius
Feb 1, 1980·Analytical Biochemistry·T Fukushima, J C Nixon
Jan 1, 1948·Journal of the American Chemical Society·J H MOWAT, J H BOOTHE


Jan 1, 1983·Journal of Inherited Metabolic Disease·S YoshiokaM Kawaguchi
Jan 1, 1984·Neurochemistry International·D HeintelR A Levine
Jun 1, 1987·Archives of Biochemistry and Biophysics·G K Smith
Sep 20, 1996·Journal of Chromatography. B, Biomedical Applications·E R WernerH Wachter

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