Abstract
We report a series of p-hydroxy-, p-amino-, p-monomethylamino-, and p-monofluoroethylamino-substituted biphenyltrienes that displayed high binding affinities to beta-amyloid plaques. In an in vitro binding assay using postmortem brain homogenates of Alzheimer's patients and [(125)I]9, the triene compounds showed excellent binding affinities. When labeled with suitable radionuclides, they are useful as in vivo imaging agents for detecting Abeta plaques in the brains of Alzheimer's patients.
References
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Nov 20, 1998·Life Sciences·W E KlunkJ W Pettegrew
Aug 10, 2000·Nature Biotechnology·D J Selkoe
Aug 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S D StyrenW E Klunk
Feb 22, 2001·Neurobiology of Aging·C D LinkW E Klunk
Jul 20, 2002·Science·John Hardy, Dennis J Selkoe
Jan 10, 2003·Journal of Medicinal Chemistry·Zhi-Ping ZhuangHank F Kung
Feb 1, 2003·The Journal of Organic Chemistry·Joel M Kauffman, Guillermo Moyna
Aug 6, 2003·Nuclear Medicine and Biology·Masahiro OnoHank F Kung
Mar 3, 2004·Annals of Neurology·William E KlunkBengt Långström
Mar 10, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Mei-Ping KungHank F Kung
Apr 21, 2004·Annals of Internal Medicine·Dennis J SelkoeUNKNOWN American Physiological Society
May 12, 2004·Current Pharmaceutical Design·C A MathisW E Klunk
Oct 7, 2004·Brain Research·Mei-Ping KungHank F Kung
Nov 17, 2004·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Nicolaas P L G VerhoeffSylvain Houle
Feb 16, 2005·Archives of Neurology·Chester A MathisSteven T DeKosky
Apr 19, 2005·Nature Biotechnology·Martin HintersteinerHans-Ulrich Gremlich
Citations
Jun 16, 2007·Journal of Medicinal Chemistry·Wenchao QuHank F Kung
Jan 11, 2013·Biological & Pharmaceutical Bulletin·Young Mi HaHae Young Chung
Sep 2, 2015·Bioorganic & Medicinal Chemistry Letters·Min WangQi-Huang Zheng
Oct 31, 2014·Journal of Medicinal Chemistry·Murat BozdagClaudiu T Supuran
Aug 21, 2007·Chembiochem : a European Journal of Chemical Biology·Qian LiYoung-Tae Chang
Dec 22, 2009·ChemMedChem·Jeyanthy SutharsanEmmanuel A Theodorakis
Mar 12, 2010·The Journal of Physical Chemistry. a·Daniela PfiffiClaus A M Seidel
Feb 17, 2009·Journal of Medicinal Chemistry·Kim SerdonsAlfons Verbruggen
Jul 30, 2009·Chemical Reviews·Lauren E Scott, Chris Orvig
Nov 3, 2009·Journal of Medicinal Chemistry·Kim SerdonsAlfons Verbruggen
Jun 13, 2014·Organic Letters·Yoshikazu HorinoKiyoshi Tsuge
Oct 25, 2014·The Journal of Organic Chemistry·Lijun WuPi Cheng
Sep 26, 2021·Journal of Fluorescence·Yoriko Sonoda