Synthesis of biphenyltrienes as probes for beta-amyloid plaques.

Journal of Medicinal Chemistry
Zhi-Ping ZhuangHank F Kung

Abstract

We report a series of p-hydroxy-, p-amino-, p-monomethylamino-, and p-monofluoroethylamino-substituted biphenyltrienes that displayed high binding affinities to beta-amyloid plaques. In an in vitro binding assay using postmortem brain homogenates of Alzheimer's patients and [(125)I]9, the triene compounds showed excellent binding affinities. When labeled with suitable radionuclides, they are useful as in vivo imaging agents for detecting Abeta plaques in the brains of Alzheimer's patients.

References

Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Aug 10, 2000·Nature Biotechnology·D J Selkoe
Aug 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S D StyrenW E Klunk
Mar 3, 2004·Annals of Neurology·William E KlunkBengt Långström
Mar 10, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Mei-Ping KungHank F Kung
Apr 21, 2004·Annals of Internal Medicine·Dennis J SelkoeUNKNOWN American Physiological Society
May 12, 2004·Current Pharmaceutical Design·C A MathisW E Klunk
Nov 17, 2004·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Nicolaas P L G VerhoeffSylvain Houle
Feb 16, 2005·Archives of Neurology·Chester A MathisSteven T DeKosky
Apr 19, 2005·Nature Biotechnology·Martin HintersteinerHans-Ulrich Gremlich

❮ Previous
Next ❯

Citations

Sep 2, 2015·Bioorganic & Medicinal Chemistry Letters·Min WangQi-Huang Zheng
Aug 21, 2007·Chembiochem : a European Journal of Chemical Biology·Qian LiYoung-Tae Chang
Dec 22, 2009·ChemMedChem·Jeyanthy SutharsanEmmanuel A Theodorakis
Mar 12, 2010·The Journal of Physical Chemistry. a·Daniela PfiffiClaus A M Seidel
Nov 3, 2009·Journal of Medicinal Chemistry·Kim SerdonsAlfons Verbruggen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.