Synthesis of bosutinib from 3-methoxy-4-hydroxybenzoic acid.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Xiao Jia YinFei Li

Abstract

This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and target molecule were characterized by (1)H-NMR, (13)C-NMR, MS and the purities of all the compounds were determined by HPLC.

References

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Nov 2, 2002·The EMBO Journal·Agata KlejmanTomasz Skorski
Oct 19, 2004·Oncogene·Sarah J Parsons, J Thomas Parsons
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Citations

Mar 19, 2014·Bioorganic & Medicinal Chemistry·Hong X DingChristopher J O'Donnell
Jun 25, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chia-Lin LeeYang-Chang Wu
Dec 14, 2018·International Journal of Molecular Sciences·Min-Chi ChengChing-Kuo Lee

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