Synthesis of carbazole bearing pyridopyrimidine-substituted sulfonamide derivatives and studies their carbonic anhydrase enzyme activity

Journal of Biochemical and Molecular Toxicology
Arleta Rifati-NixhaOktay Arslan

Abstract

The synthesis of carbazole containing pyridopyrimidine-substituted sulfonamide derivatives (3a-i) and their inhibitory effects on human carbonic anhydrase (hCA) I and II were studied. Spectral data and elemental analysis confirmed the structures of the compounds synthesized. The results show that all the synthesized compounds inhibited the CA I and II activities. Among them, 3a was found to be the most active ( K i : 14 µM) for hCA I and 3f ( K i : 126 µM) for hCA II.

References

Jul 1, 1990·Journal of Medicinal Chemistry·C D SelassieT A Khwaja
Dec 1, 1996·Epilepsy Research·M Khurgel, G O Ivy
Mar 1, 1997·Bioorganic & Medicinal Chemistry·O ArslanB Nalbantoĝlu
Apr 8, 2003·Current Medicinal Chemistry·Andrea ScozzafavaClaudiu T Supuran
May 13, 2003·Journal of Combinatorial Chemistry·Jae Wook LeeYoung-Tae Chang
Oct 11, 2003·The Journal of Organic Chemistry·Rina PandyaAnthony G M Barrett
Jan 27, 2004·Bioorganic & Medicinal Chemistry Letters·William G HarterNigel Walker
Jan 30, 2004·Journal of the American Chemical Society·Stephen CaddickDuncan B Judd
Jul 1, 2004·Bioorganic & Medicinal Chemistry Letters·Natala Srinivasa ReddyM V Ramana Reddy
Oct 27, 2004·Journal of Enzyme Inhibition and Medicinal Chemistry·Silvia PastorekovaClaudiu T Supuran
Nov 18, 2004·Bioorganic & Medicinal Chemistry Letters·Sabrina ZimmermanClaudiu T Supuran
Jul 27, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·I Roth-DeriG Yadid
Aug 30, 2005·Bioorganic & Medicinal Chemistry·Anu AgarwalSuman Gupta
Nov 5, 2005·The Journal of Organic Chemistry·Alan R KatritzkyHui Tao
Jan 28, 2006·The Journal of Organic Chemistry·Stephen W Wright, Kelly N Hallstrom
Apr 29, 2006·Bioorganic & Medicinal Chemistry Letters·Brent R StranixJinzi J Wu
Feb 12, 2009·Journal of the American Chemical Society·Alfonso MarescaClaudiu T Supuran
Jun 10, 2010·Bioorganic & Medicinal Chemistry Letters·Claudiu T Supuran
Jul 2, 2010·Journal of Medicinal Chemistry·Fabrizio CartaClaudiu T Supuran
Sep 11, 2010·European Journal of Medicinal Chemistry·David VásquezJaime A Valderrama
Jun 15, 2011·Bioorganic & Medicinal Chemistry Letters·Sevim Beyza Oztürk SarikayaClaudiu T Supuran
Jan 5, 2013·European Journal of Medicinal Chemistry·Pranjali JainSushil Kumar Singh
Jan 18, 2013·Journal of Enzyme Inhibition and Medicinal Chemistry·Fatma CelikNahit Gençer
Jan 24, 2013·Journal of Enzyme Inhibition and Medicinal Chemistry·Fatih SonmezMustafa Kucukislamoglu
May 10, 2013·Artificial Cells, Nanomedicine, and Biotechnology·Mert Olgun KarataşOktay Arslan

❮ Previous
Next ❯

Citations

Sep 19, 2020·Chemical Biology & Drug Design·Pratibha Yadav, Kamal Shah

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.