PMID: 591466Nov 1, 1977

Synthesis of carbon-14 and tritium labeled sagamicin

The Journal of Antibiotics
T DeguchiM Tanaka

Abstract

Sagamicin, an aminoglycoside antibiotic, was labeled with tritium by means of a platinum catalyzed hydrogen exchange reaction and by carbon-14 in two biosynthetic procedures. 14C-Methyl-L-methionine was used as the radioactive precursor in these biological processes involving Micromonospora sagamiensis. The distribution of radioactivity in 14C-sagamicin and gentamicin C1 was studied by mild acid hydrolysis and Hofmann degradation. The results showed that both C- and N-methyl groups were derived from methionine. One of the biosynthetic processes involved the conversion of gentamicin into sagamicin with resting cells and labeled methionine.

Citations

Sep 23, 2006·Science in China. Series C, Life Sciences·Mingxuan XuGuoping Zhao

Related Concepts

Carbon Radioisotopes
Gentacycol
Pedameth
Micromonospora
Tritium

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