Synthesis of cationic glucosamino nucleic acids for stabilizing oligonucleotides

Bioorganic & Medicinal Chemistry Letters
Yoshiaki KitamuraYukio Kitade

Abstract

Glucosamino nucleic acids (GANAs) bearing a β-N-glycoside bond between carbon 1 of the glucosamine and the nucleobase nitrogen were synthesized and incorporated into oligonucleotides (4',6'-GANA and 3',6'-GANA). The thermal stability of oligonucleotide duplexes containing the GANA zwitterionic nucleotides was also investigated.

Citations

Mar 2, 2021·Chemical Society Reviews·Luke K McKenzieMarcel Hollenstein

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