PMID: 19915649Nov 17, 2009Paper

Synthesis of cationic lipid transfection agents with O,O- or N,O-acetal bonds

Bioorganicheskaia khimiia
M A MaslovG A Serebrennikova

Abstract

The synthesis of cationic lipids on the basis of 1,2-di-O-tetradecylglycerol is described. The cationic groups represented by the residues of nitrogen-containing heterocyclic bases are attached to the diglyceride backbone through O,O- and N,O-acetal bonds. The resulting lipids can be used as nonviral gene delivery systems to eukaryotic cells.

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Citations

Sep 24, 2013·Organic & Biomolecular Chemistry·Ekaterina A IvanovaMarina A Zenkova

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