PMID: 9440349Jan 24, 1998Paper

Synthesis of certain 5-substituted 2-thiohydantoin derivatives as potential cytotoxic and antiviral agents

Bollettino chimico farmaceutico
A I KhodairA A el-Emam

Abstract

A convenient route is reported for the synthesis of certain series of 2-thiohydantoins carrying various heterocyclic substituents such as 5-bromothienylidene 3a,b, 5-(2-carboxyphenylthio)-2-thienylidene 4a,b and 4H-thieno[2,3-b][1]benzothiopyran-4-one 5a,b. Glycosylation of these thiohydantoins afforded the S-glycosyl derivatives 10a-d. The synthesized compounds were tested for their activity against HIV-1 virus and as antitumor agents.

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