Synthesis of chalcone derivatives on steroidal framework and their anticancer activities

Hari Om SaxenaArvind Singh Negi


Chalcone derivatives on estradiol framework have been synthesized. Some of the derivatives showed potent anticancer activity against some human cancer cell lines. Compounds 9 and 19 showed potent activity against MCF-7, a hormone dependent breast cancer cell line. Chalcone 7 was further modified to the corresponding indanone derivative (19) using the Nazarov reaction, which showed better activity than the parent compound against the MCF-7 breast cancer cell line. Active anticancer derivatives were also evaluated for osmotic hemolysis using the erythrocyte as a model system. It was observed that chalcone derivatives showing cytotoxicity against cancer cell lines did not affect the fragility of erythrocytes and hence may be considered as non-toxic to normal cells.


May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S DauvoisM G Parker
Jun 1, 1983·British Journal of Haematology·B E Burke, D M Shotton
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·R J D'AmatoE Hamel
Jun 1, 1993·Journal of Natural Products·H J WoerdenbagA W Konings
Jan 1, 1995·Die Nahrung·M Krajcovicová-KudláckováE Grancicová
Apr 25, 2003·The Journal of Steroid Biochemistry and Molecular Biology·H SeegerJ Huober
Dec 26, 2003·Cell Biochemistry and Function·M Vijayamalini, S Manoharan
May 27, 2004·Journal of Agricultural and Food Chemistry·Laura SvetazSusana A Zacchino
Aug 25, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S SirichotiyakulT Tongsong
May 13, 2005·Journal of Medicinal Chemistry·José DomínguezPhilip J Rosenthal
Sep 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christopher SweeneyGeorge Wilding
Nov 3, 2005·Bioorganic & Medicinal Chemistry·Sarot CheenprachaSupinya Tewtrakul
Nov 22, 2005·Bioorganic & Medicinal Chemistry Letters·Vandana SrivastavaSuman P S Khanuja
Nov 26, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Y L HsuC C Lin
Jan 3, 2006·Bioorganic & Medicinal Chemistry·Paula BoeckBartira Rossi-Bergmann
Jan 26, 2006·Bioorganic & Medicinal Chemistry·Aneta ModzelewskaSaeed R Khan
Jan 31, 2006·Journal of Natural Products·Toshihiro AkihisaHoyoku Nishino
Feb 14, 2006·Critical Reviews in Oncology/hematology·Anthony Howell
Feb 17, 2006·European Journal of Pharmacology·Sung Hee LeeDong Hwan Sohn
Jul 1, 1947·The Journal of Clinical Investigation·A K ParpartA M Chase
Sep 5, 2006·Bioorganic & Medicinal Chemistry Letters·Nicholas J LawrenceSylvie Ducki
Oct 27, 2006·Bioorganic & Medicinal Chemistry·Hyun-Mo YangSang-Hun Jung


Jan 1, 2010·Acta Crystallographica. Section E, Structure Reports Online·Hoong-Kun FunChatchanok Karalai
Nov 26, 2013·Experimental Parasitology·Tatiane F P de MelloThais G V Silveira
Sep 23, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Yusif S El-Sayed, M Gaber
Sep 4, 2009·Journal of Hematology & Oncology·Subhash PadhyeFazlul H Sarkar
Sep 24, 2013·European Journal of Medicinal Chemistry·Vishal SharmaMohan Paul S Ishar
Apr 29, 2010·Natural Product Reports·James R Hanson
Oct 26, 2013·Journal of Photochemistry and Photobiology. B, Biology· ShamsuzzamanAamir Sohail
Jan 26, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Cem YamaliClaudiu T Supuran
Jun 7, 2014·Pharmacological Reports : PR·Jian ZhangShi-Xing Qiao
Nov 13, 2012·Bioorganic & Medicinal Chemistry·Miroslav KvasnicaLadislav Kohout
Sep 29, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Debabrata ChandaArvind Singh Negi
May 29, 2012·The Journal of Steroid Biochemistry and Molecular Biology·Bridgette M Collins-BurowMatthew E Burow
Jul 21, 2011·Steroids·Abid H BandayBashir A Ganaie
Sep 2, 2009·International Immunopharmacology·Elena NicolisGiulio Cabrini
Jul 1, 2008·Bioorganic & Medicinal Chemistry Letters·Hari Om SaxenaSuman P S Khanuja
Nov 19, 2013·Chemistry & Biodiversity·Suelem Demuner RamalhoKristiana Cerqueira Mousinho
Aug 8, 2015·Journal of Fluorescence·Ayaz Mahmood Dar Shamsuzzaman
Mar 31, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Halise Inci GulClaudiu T Supuran
Sep 23, 2014·European Journal of Medicinal Chemistry·B Sathish KumarArvind Singh Negi
Apr 5, 2012·Bioorganic & Medicinal Chemistry·A P PrakashamArvind Singh Negi
Jun 4, 2013·The Journal of Steroid Biochemistry and Molecular Biology·Atul GuptaArvind Singh Negi
Sep 12, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Shams UzzamanYusuf Khan
May 30, 2014·Chemical Reviews·Ranju Bansal, Pratap Chandra Acharya
May 11, 2011·Pharmaceutical Biology·Arvind Singh NegiMahendra Pandurang Darokar
Aug 6, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Svetlana K VorontsovaValerii Z Shirinian

Related Concepts

Antineoplastic Agents
Estradiol, (16 alpha,17 beta)-Isomer
Cell Line, Tumor

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.