Synthesis of chitin-glucan-aldehyde-quercetin conjugate and evaluation of anticancer and antioxidant activities

Carbohydrate Polymers
Anu SinghAmbak Kumar Rai

Abstract

In the present study, we have synthesized chitin-glucan-aldehyde-quercetin (chi-glu-ald-que) conjugate via condensation reaction. Synthesis of chitin-glucan-aldehyde (chi-glu-ald) complex was facilitated by the oxidation of chitin-glucan (chi-glu) complex. Formation of conjugate was confirmed by Proton nuclear magnetic resonance spectroscopy (1H NMR) and Fourier-transform infrared spectroscopy (FT-IR). Morphological studies showed that after grafting of quercetin, several changes on surface were depicted and a more crystalline nature was observed. The chi-glu-ald-que conjugate displayed strong antioxidant activity. It showed 69% of 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical, DPPH* scavenging activity at 1 mg/mL and 72% of 2, 2-azinobis-(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radical cation, ABTS*+ scavenging activity at 1 mg/mL concentration, which are much higher than that of chi-glu complex. The anticancer activity of chi-glu-ald-que conjugate was performed in Macrophage cancer cell lines (J774) and biocompatibility was performed in Peripheral blood mononuclear cells (PBMCs). The chi-glu-ald-que conjugate showed excellent cytotoxicity against J774 cell lines but no cytotoxicity towards PBMCs.

Citations

Apr 30, 2020·International Journal of Nanomedicine·Heshu Sulaiman RahmanNoorjahan Banu Alitheen
Jan 17, 2020·International Journal of Molecular Sciences·Yukun Qin, Pengcheng Li
Dec 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Saravut Satitsri, Chatchai Muanprasat
Mar 2, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Premjit ArpornmaeklongSupakorn Boonyuen
Apr 23, 2021·International Journal of Biological Macromolecules·Bingren TianYumei Liu
Aug 7, 2021·Ultrasonics Sonochemistry·Muhammad Faisal ManzoorBin Xu

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