Synthesis of chroman analogues of lipoic acid and evaluation of their activity against reperfusion arrhythmias

Bioorganic & Medicinal Chemistry
Maria KoufakiP Papazafiri

Abstract

Novel hybrids of lipoic acid and trolox connected through triamine spacers as well as analogues in which the lipoic acid was attached at different positions of the chroman moiety of vitamin E through an amide bond, were synthesized and exhibited strong inhibition of the microsomal lipid peroxidation. Moreover, the new molecules, at 1 microM concentration, reduced reperfusion arrhythmias and MDA content on isolated rat heart preparations, with the 2- and 5-subtituted chromans possessing the better cardioprotective activity.

Citations

May 25, 2005·Bioorganic & Medicinal Chemistry Letters·Heesoon LeeEmmanuel A Theodorakis
Nov 22, 2005·Free Radical Research·Athanassios Vassilopoulos, Panagiota Papazafiri
Oct 31, 2015·Expert Opinion on Therapeutic Patents·Maria Koufaki
Aug 8, 2014·Expert Opinion on Therapeutic Patents·Maria Koufaki
Nov 25, 2005·Drug Development and Industrial Pharmacy·M L N DubuissonJ Marchand-Brynaert
Jan 15, 2014·Chemical Biology & Drug Design·Maria Laura BolognesiMichael Smietana
Sep 25, 2015·Journal of the American Chemical Society·Pu-Sheng WangLiu-Zhu Gong
Jun 28, 2016·European Journal of Medicinal Chemistry·Ol'ga D ZakharovaGeorgy A Nevinsky
Jan 12, 2016·Nature Communications·Jasper H M van der VeldeThorben Cordes
Dec 7, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Vita M VecchioFrancesco P Fanizzi
Dec 5, 2013·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Jasper H M van der VeldeThorben Cordes
Jul 21, 2020·Journal of Medicinal Chemistry·Shikha KumariPaul C Trippier

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