Synthesis of diagnostic quality cancer pathology images by generative adversarial networks.

The Journal of Pathology
Adrian B. LevineAli Bashashati

Abstract

Deep learning-based computer vision methods have recently made remarkable breakthroughs in the analysis and classification of cancer pathology images. However, there has been relatively little investigation of the utility of deep neural networks to synthesize medical images. In this study, we evaluated the efficacy of generative adversarial networks to synthesize high-resolution pathology images of 10 histological types of cancer, including five cancer types from The Cancer Genome Atlas and the five major histological subtypes of ovarian carcinoma. The quality of these images was assessed using a comprehensive survey of board-certified pathologists (n = 9) and pathology trainees (n = 6). Our results show that the real and synthetic images are classified by histotype with comparable accuracies and the synthetic images are visually indistinguishable from real images. Furthermore, we trained deep convolutional neural networks to diagnose the different cancer types and determined that the synthetic images perform as well as additional real images when used to supplement a small training set. These findings have important applications in proficiency testing of medical practitioners and quality assurance in clinical laboratories. Fur...Continue Reading

References

Jan 19, 2006·Annals of Internal Medicine·Lucian L Leape, John A Fromson
Apr 8, 2010·Science Translational Medicine·William C McGaghie
May 28, 2010·The American Journal of Surgical Pathology·Martin KöbelC Blake Gilks
Oct 25, 2012·Biochemia Medica·Mary L McHugh
Jul 25, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Martin KöbelUNKNOWN Ovarian Tumor Tissue Analysis consortium
Dec 20, 2014·Genetics and Molecular Research : GMR·H M LiuF Ou
Sep 16, 2016·British Journal of Cancer·Stefan KommossFriedrich Kommoss
Sep 23, 2016·The New England Journal of Medicine·Robert L GrossmanLouis M Staudt
Oct 18, 2016·Analytical Cellular Pathology (Amsterdam)·Spoorthi Ravi BanavarPremalatha Bidadi Rajashekaraiah
Apr 26, 2017·Archives of Pathology & Laboratory Medicine·Andrew J EvansLiron Pantanowitz
Dec 14, 2017·JAMA : the Journal of the American Medical Association·Babak Ehteshami BejnordiRui Venâncio
Mar 14, 2018·Proceedings of the National Academy of Sciences of the United States of America·Pooya MobadersanyLee A D Cooper
Oct 13, 2018·The American Journal of Surgical Pathology·David F SteinerMartin C Stumpe
Jan 9, 2019·Nature Medicine·W Nicholson Price, I Glenn Cohen
Mar 23, 2019·Trends in Cancer·Adrian B LevineStephen Yip
Jul 10, 2019·IEEE Transactions on Medical Imaging·Faisal MahmoodNicholas J Durr
Sep 16, 2019·Medical Image Analysis·Xin YiPaul Babyn

❮ Previous
Next ❯

Citations

Nov 4, 2020·The Journal of Pathology·Amir SafarpoorHamid R Tizhoosh
Apr 16, 2021·The Journal of Clinical Investigation·Toby C Cornish
May 21, 2021·Journal of Pathology Informatics·André HomeyerPeter Hufnagl
Jul 30, 2021·Current Opinion in Ophthalmology·Zhaoran WangDaniel Shu Wei Ting

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

BioRxiv : the Preprint Server for Biology
Adrian B. LevineAli Bashashati
IEEE Transactions on Medical Imaging
Hojjat SalehinejadShahrokh Valaee
Neural Networks : the Official Journal of the International Neural Network Society
Shaista HussainAmit Singhal
© 2021 Meta ULC. All rights reserved