Synthesis of dimeric acridine derived antivirals

Bioorganic & Medicinal Chemistry Letters
René CsukChristian Raschke

Abstract

A series of antiviral compounds consisting of an intercalating acridine derived part, a spacer region and a reactive EDTA derived conjugate was synthesized in an easy sequence starting from 1,omega-alkyldiamines. As shown in model screenings, in the presence of ascorbic acid the Fe-complexes of these compounds reduced the phage-titer of MS2-phages by >8 logarithmic decades.

References

Jan 1, 1990·Free Radical Research Communications·M J Burkitt, B C Gilbert
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L A LoebS J Klebanoff
Dec 1, 1983·European Journal of Biochemistry·A SamuniG Czapski

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Citations

Apr 2, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Vivianne Mendes MangueiraMarianna Vieira Sobral

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