Synthesis of diversely functionalised 2,2-disubstituted oxetanes: fragment motifs in new chemical space

Chemical Communications : Chem Comm
Owen A DavisJames A Bull

Abstract

Di-, tri- and tetra-substituted oxetane derivatives with combinations of ester, amide, nitrile, aryl, sulfone and phosphonate substituents are prepared as fragments or building blocks for drug discovery. The synthesis of these novel oxetane functional groups, in new chemical space, is achieved via rhodium-catalysed O-H insertion and C-C bond forming cyclisation.

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Citations

Sep 16, 2016·Chemical Reviews·James A BullKate F Morgan
Oct 11, 2016·The Journal of Organic Chemistry·Owen A DavisJames A Bull
Oct 22, 2016·Angewandte Chemie·Daniel J FoleyStephen P Marsden
Apr 27, 2019·Chemistry : a European Journal·Rong ZhangAdam Nelson
Aug 21, 2019·Chemistry : a European Journal·Oleksandr O GrygorenkoDuncan B Judd
Apr 4, 2017·Chemical Communications : Chem Comm·Junxiang MinJiangtao Sun
Jan 28, 2020·Organic Process Research & Development·Sebastian P GreenJames A Bull
Nov 6, 2020·International Journal of Molecular Sciences·Fernando Rodrigues de Sá AlvesStefan Laufer
Apr 12, 2019·The Journal of Organic Chemistry·Maryne A J DuboisJames A Bull
Sep 22, 2021·Organic & Biomolecular Chemistry·Kien P MalarneyValerie A Schmidt

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