Synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines (PBDs)

Chemical Reviews
Dyeison Antonow, David E Thurston

Abstract

No abstract listed.

References

Mar 1, 1985·Journal of Medicinal Chemistry·T KanekoW T Bradner
Sep 25, 1968·Journal of the American Chemical Society·W LeimgruberR C Czajkowski
Sep 2, 2000·Bioorganic & Medicinal Chemistry Letters·Stephen J GregsonDavid E Thurston
Sep 2, 2000·Bioorganic & Medicinal Chemistry Letters·Stephen J GregsonDavid E Thurston
Sep 22, 2000·Bioorganic & Medicinal Chemistry Letters·M J SagnouDavid E Thurston
Nov 30, 2000·Nucleosides, Nucleotides & Nucleic Acids·P G BaraldiR Gambari
Feb 24, 2001·Bioorganic & Medicinal Chemistry Letters·Ahmed KamalS Raghavan
Jul 18, 2001·Journal of the American Chemical Society·Q ZhouLaurence Hurley
Oct 13, 2001·Bioorganic & Medicinal Chemistry Letters·Stephen J GregsonDavid E Thurston
Nov 15, 1996·The Journal of Organic Chemistry·David E ThurstonLaurence Hurley
Oct 24, 2001·The Journal of Organic Chemistry·Tatsuo Nagasaka, Yuji Koseki
May 7, 2002·Bioorganic & Medicinal Chemistry Letters·Jane M BerryDavid E Thurston
Jul 13, 2002·Bioorganic & Medicinal Chemistry Letters·Ahmed KamalG Ramesh
Oct 31, 2002·Chembiochem : a European Journal of Chemical Biology·Elisabeth AddicksAthanassios Giannis
Apr 8, 2003·Mini Reviews in Medicinal Chemistry·Rohtash Kumar, J William Lown
May 16, 2003·Journal of Medicinal Chemistry·Moana TercelWilliam A Denny
Sep 25, 2003·Bioorganic & Medicinal Chemistry Letters·Ahmed KamalG Ramesh
Sep 25, 2003·Bioorganic & Medicinal Chemistry Letters·Ahmed KamalP Praveen Kumar
Nov 1, 2003·Bioorganic & Medicinal Chemistry Letters·Ahmed KamalG Ramesh
Dec 31, 2003·Bioorganic & Medicinal Chemistry Letters·Ahmed KamalP Ramulu
Mar 12, 2004·Bioorganic & Medicinal Chemistry Letters·Luke A MastersonDavid E Thurston
Jul 1, 2004·Bioorganic & Medicinal Chemistry Letters·Ahmed KamalP Praveen Kumar
Aug 25, 2004·Bioorganic & Medicinal Chemistry Letters·Ahmed KamalP Praveen Kumar
Sep 3, 2004·Bioorganic & Medicinal Chemistry Letters·Ahmed KamalRenu Moti Pandita
Oct 16, 2004·Bioorganic & Medicinal Chemistry Letters·Ahmed KamalY L N Murthy
Nov 18, 2004·Bioconjugate Chemistry·Zhanna V ZhilinaScot W Ebbinghaus
Feb 25, 2005·Bioorganic & Medicinal Chemistry·Ahmed KamalM Shiva Kumar
Jul 9, 2005·Angewandte Chemie·Patrick DeckHerbert Waldmann
Nov 5, 2005·Organic Letters·Stephanie L MacQuarrie-Hunter, Paul R Carlier
Dec 20, 2005·Bioorganic & Medicinal Chemistry Letters·Ahmed Kamal Rajendar
Mar 11, 2006·Chemistry : a European Journal·Markus BielHerbert Waldmann
Nov 23, 2006·Bioorganic & Medicinal Chemistry Letters·Rachel L ClarkSimon P Mackay
Nov 23, 2006·Bioorganic & Medicinal Chemistry Letters·Ahmed KamalP S Murali Mohan Reddy
Nov 23, 2006·Journal of the American Chemical Society·Paul R CarlierDanny C Hsu
Apr 3, 2007·Journal of Combinatorial Chemistry·Dyeison AntonowDavid E Thurston
Jan 10, 2009·Bioorganic & Medicinal Chemistry·Wan-Ping HuJeh-Jeng Wang
Feb 10, 2009·Current Drug Targets·K D Bagshawe
Mar 12, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel HochhauserDuncan I Jodrell
Apr 25, 2009·Journal of Natural Products·Serge FotsoTaifo Mahmud
Aug 13, 2009·Cancer Chemotherapy and Pharmacology·Yelena Y JanjigianNaiyer A Rizvi
Feb 23, 2010·European Journal of Medicinal Chemistry·Ahmed KamalManika Pal Bhadra
Mar 12, 2010·Journal of Medicinal Chemistry·Dyeison AntonowDavid E Thurston
May 7, 2010·Bioorganic & Medicinal Chemistry Letters·Ahmed KamalSurekha Zingde
Jun 18, 2010·European Journal of Medicinal Chemistry·Ahmed KamalShasi V Kalivendi
Oct 5, 2010·Bioorganic & Medicinal Chemistry Letters·Keisuke MaruyamaMinoru Ishikawa

Citations

Jan 22, 2011·Organic & Biomolecular Chemistry·Khondaker Miraz RahmanDavid E Thurston
May 2, 2012·The Journal of Antimicrobial Chemotherapy·Khondaker Miraz RahmanPeter W Taylor
Oct 5, 2012·BMC Chemical Biology·Maralinganadoddi Panchegowda SadashivaKanchugarakoppal Subbegowda Rangappa
Feb 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·George Varvounis
Oct 21, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karl HemmingPaul A O'Gorman
Mar 12, 2015·Pharmaceutical Research·Nareshkumar JainBruce Tomczuk
Mar 20, 2013·Pharmacology & Therapeutics·Michael P BarrettColin J Suckling
Sep 21, 2011·Journal of the American Chemical Society·Khondaker Miraz RahmanDavid E Thurston
Aug 19, 2014·PloS One·Khondaker Miraz RahmanDavid E Thurston
Jan 4, 2017·Organic & Biomolecular Chemistry·Ruijia WangJiannan Xiang
Oct 8, 2016·Organic & Biomolecular Chemistry·K N Visweswara SastryAhmed Kamal
Mar 29, 2014·Angewandte Chemie·Ravi V J ChariWayne C Widdison
Nov 20, 2016·Angewandte Chemie·Julia MantajDavid E Thurston
Aug 29, 2019·Organic & Biomolecular Chemistry·Jitendra GourSrinivas Nanduri
Jun 20, 2019·Journal of Cellular Physiology·Sajad YaghoubiMeghdad Abdollahpour-Alitappeh
Jul 31, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Donglu ZhangCornelis E C A Hop
Aug 6, 2020·International Journal of Molecular Sciences·Sara PonzianiFrancesco Giansanti
May 24, 2017·Nature Reviews. Clinical Oncology·Joshua K SabariCharles M Rudin
Jan 20, 2018·Molecular Cancer Therapeutics·Donglu ZhangCornelis E C A Hop
Mar 19, 2021·ACS Medicinal Chemistry Letters·Prasanna SivaprakasamSanjeev Gangwar

Related Concepts

Pyrrolobenzodiazepine
Benzodiazepines
DNA, Double-Stranded
Pyrroles
pyrrolo(2,1-c)(1,4)benzodiazepine

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