PMID: 8942061May 1, 1996Paper

Synthesis of ethylammonium iodides of omega-dialkylaminoethyl ethers of 5-(arylmethylene)-1,3,3-trimethyl-2-oxabicyclo [2.2.2.] octan-6-hydroxyimines as potential cosmetic ingredients

Bollettino chimico farmaceutico
E MarianiS Dorato

Abstract

The synthesis of nine quaternary ammonium iodides derived from omega-dialkylaminoethyl ethers of 5-(arylmethylene)-1,3, 3-trimethyl-2-oxabicyclo[2.2.2]octan-6-hydroxyimines, as potential cosmetic ingredients, is described. They are routinely prepared starting from cineole aminoethers by reaction with iodoethane and their physics-chemical data are reported. These substances were studied for their UV absorption and three of these compounds were also submitted to microbiological assays on five test organisms. The substances have their UV absorption maxima at 284-321 nm, and one compound is active on Staphylococcus aureus, Streptococcus faecalis and Candida albicans. These preliminary findings seem to indicate that some of these compounds could be considered as potential UV sunscreens; one compound, having a moderate antimicrobial activity, could be considered a potential active compound in cosmetics as deodorants, toothpastes, mouthwashes and other oral care products.

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