Synthesis of fast myosin induced by fast ectopic innervation of rat soleus muscle is restricted to the ectopic endplate region

Nature
G SalviatiM Aloisi

Abstract

Skeletal muscle fibres, long multinucleated cells, arise by fusion of mononucleated myoblasts to form a myotube that matures into the adult fibre. The two major types of mature fibre, fast and slow fibres, differ physiologically in their rate of isotonic shortening. At the molecular level these type-specific physiological properties are ascribed to different isoforms of myosin, a major protein involved in shortening. Differentiation of fast and slow fibres seems to be under the control of motoneurones, and mature fibres are innervated by only one motoneurone. When rat soleus muscle (SOL, a slow muscle) is dually innervated with a fast nerve, it acquires some properties of a fast muscle, that is, low sensitivity to caffeine and high glycogen content. We report here that in dually innervated soleus muscle the foreign fast nerve induces synthesis of fast isoforms of myosin, but only in the segment of the muscle fibre that is close to the foreign endplate. The localized influence of the nerve endplates suggest that factors controlling the phenotypic expression of the muscle fibre have a short range of activity.

References

Feb 1, 1978·The Journal of Physiology·T Lømo, C R Slater
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jan 1, 1976·Annual Review of Physiology·E Gutmann
Sep 1, 1975·Acta Physiologica Scandinavica·E FrankH Sommerschild
Nov 1, 1975·The Journal of Physiology·T Lomo, R H Westgaard
Jan 1, 1986·The Journal of Cell Biology·G K Pavlath, H M Blau
Jul 1, 1967·The Journal of General Physiology·M Bárány
Jan 1, 1972·Physiological Reviews·R I Close
Oct 1, 1968·Physiological Reviews·L Guth
Jun 24, 1980·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·D P KufflerJ K Jansen
Jan 1, 1983·Progress in Neurobiology·J J McArdle
Apr 15, 1983·Experimental Cell Research·P M Frair, A C Peterson
Sep 1, 1983·The Journal of Cell Biology·G F GauthierA W Hobbs

❮ Previous
Next ❯

Citations

Feb 19, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·B W RosserE Bandman
Jan 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·K M McCormick, E Schultz
Nov 27, 2002·Muscle & Nerve·Derron L Bishop, Richard L Milton
Apr 1, 1993·Pflügers Archiv : European journal of physiology·A L ConnoldR Zak
May 1, 1987·Pflügers Archiv : European journal of physiology·R S StaronD Pette
Aug 10, 2006·European Journal of Applied Physiology·Menotti Midrio
Aug 11, 2005·Pflügers Archiv : European journal of physiology·Fawzi KadiMichael Kjaer
Apr 1, 1995·Progress in Neurobiology·L Larsson, T Ansved
May 31, 1989·Biochimica Et Biophysica Acta·A Martonosi
Jan 1, 1991·Neuromuscular Disorders : NMD·J B Miller
May 13, 1998·Acta Physiologica Scandinavica·K Gundersen
Aug 26, 1998·Acta Physiologica Scandinavica·S SchiaffinoM Murgia
Nov 3, 2010·Biological Reviews of the Cambridge Philosophical Society·Kristian Gundersen
Feb 1, 1992·Acta Physiologica Scandinavica·L Larsson
Aug 1, 1995·The Anatomical Record·B W RosserE Bandman
Aug 26, 1998·The Journal of Physiology·A WindischT Lømo
Apr 1, 1995·Microscopy Research and Technique·T SoukupL E Thornell
Dec 1, 1989·Cell·Z W Hall, E Ralston
Feb 9, 1989·Nature·G K PavlathH M Blau
Dec 1, 2019·The Journal of Experimental Biology·Scott Medler
Feb 1, 1990·Journal of Muscle Research and Cell Motility·J JacobyJ I Rushbrook
Oct 11, 2020·Nature Communications·Matthieu Dos SantosPascal Maire
Jan 1, 1992·The American Journal of Physiology·B Russell, D J Dix
Mar 24, 2021·The FEBS Journal·Michael Attwaters, Simon M Hughes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.