PMID: 5900216Jan 1, 1966

Synthesis of fatty acid anhydrides by reaction with dicyclohexylcarbodiimide.

Journal of Lipid Research
Z Selinger, Y Lapidot


A simple method is described for the preparation of caprylic, palmitic, stearic, and oleic anhydrides. Reaction of the free fatty acid and dicyclohexylcarbodiimide in carbon tetrachloride at room temperature gives the corresponding anhydrides in high yield (87-94%).

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Science of Chemistry
Saturated Fat
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