Synthesis of folic acid functionalized terbium-doped dendritic fibrous nano-silica and Interaction with HEK 293 normal, MDA breast cancer and HT 29 colon cancer cells.

Journal of Molecular Recognition : JMR
Sajjad AziziNasrin Shadjou

Abstract

A novel folic acid functionalized terbium-doped dendritic fibrous nanoparticle (Tb@KCC-1-NH2 -FA) with high surface area was synthesized using a novel hydrothermal protocol. In the present work, we report the fluorescent Tb-doted nanomaterial with emission wavelength at 497 nm which confirms the formation of Tb@KCC-1-NH2 -FA. Synthesized nanoparticles were investigated through transmission electron microscope, field emission scanning electron Microscopy, Fourier transform infrared spectra, Brunauer-Emmett-Teller, energy dispersive X-ray, Zeta potential and particle size distribution values and AFM (Atomic force microscopy) techniques. Specially, our desired nanomaterial which has FA moieties on the surface of Tb@KCC-1-NH2-FA where interact with folate receptor (FR) which there is on the surface of the various cancer cells. For this purpose, fluorescence microscopy images were used to prove the uptake of FA based nanomaterial with FR-positive MDA breast cancer and HT 29 colon cancer cells. Also HEK 293 normal cells as FR-negative cells verified the specificity of our desired nanomaterial toward the FR-positive cells. The cytotoxicity survey of Tb@KCC-1-NH2 -FA was examined by MTT assays against MDA breast cancer, HT 29 colon can...Continue Reading

References

Oct 12, 2005·Biotechnology Annual Review·Michael V BerridgeAn S Tan
Mar 14, 2007·Analytical Chemistry·Joshua E SmithWeihong Tan
Aug 4, 2010·Angewandte Chemie·Vivek PolshettiwarJean Marie Basset
Aug 20, 2011·Luminescence : the Journal of Biological and Chemical Luminescence·Jamshid L ManzooriAbolghasem Jouyban
Apr 10, 2012·Molecular Pharmaceutics·Yi ZhouJianhai Chen
Jul 9, 2013·European Journal of Medicinal Chemistry·Mohamed A El-BoraiIbrahim Y El-Deeb
Dec 3, 2014·Ecotoxicology and Environmental Safety·Qing YangXiaohua Huang
Apr 28, 2016·Scientific Reports·Nisha BayalVivek Polshettiwar
Mar 10, 2017·ACS Applied Materials & Interfaces·Rajendra K SinghHae-Won Kim

❮ Previous
Next ❯

Citations

Oct 17, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Roghayyeh BaghbanMahdi Rahimi

❮ Previous
Next ❯

Related Concepts