Synthesis of G0 aminopolyol and aminosugar dendrimers, controlled by NMR and MALDI TOF mass spectrometry

Designed Monomers and Polymers
Mikołaj A PyziakGrzegorz Schroeder

Abstract

Organic compounds designed to serve as stable dendrimer cores were developed. A series of aminosugar and amino polyol containing G0 dendrimers were synthesized. The reaction mixture composition was checked by MALDI TOF mass spectrometry, while that of purified products - by1H and13C NMR combined with 2D NMR spectroscopy as well as MALDI TOF MSMS mass spectra. Mass spectrometric fragmentation experiments were performed in positive ion mode in order to determine common fragmentation patterns of [M+H]+ions.

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Methods Mentioned

BETA
nuclear magnetic resonance
Nuclear
NMR
column chromatography

Software Mentioned

MassLynx

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