PMID: 2495537Apr 1, 1989Paper

Synthesis of germ-line gamma 1 immunoglobulin heavy-chain transcripts in resting B cells: induction by interleukin 4 and inhibition by interferon gamma

Proceedings of the National Academy of Sciences of the United States of America
M T BertonE S Vitetta

Abstract

Interleukin 4 (IL-4) induces the expression of IgG1 and IgE in lipopolysaccharide-stimulated B cells. Previous studies have suggested that heavy-chain class switching may be regulated by increasing the accessibility of specific switch regions to switch recombinases. In this study, we have used an RNase protection assay to demonstrate that IL-4 induces expression of germ-line gamma 1 transcripts in B cells within 4 hr of culture; induction is dose-dependent and is inhibited by interferon gamma. IL-4 alone is capable of inducing the expression of germ-line gamma 1 transcripts in small, resting B cells, but lipopolysaccharide enhances expression. The germ-line transcripts are the same size (1.8 and 3.4 kilobases) as the secreted and membrane forms of the functional gamma 1 mRNAs and presumably result from the splicing of an upstream switch-region exon(s) to the gamma 1 constant-region exon(s). These data strongly support the "accessibility" model for the regulation of isotype switching and suggest that lymphokines such as IL-4 may direct specific switch events by transcriptional activation of the corresponding switch regions.

References

Jul 25, 1979·Nucleic Acids Research·J RogersW Salser
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A J Berk, P A Sharp
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K P Dudov, R P Perry
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J StavnezerE Severinson
Feb 1, 1986·Immunological Reviews·F W AltG D Yancopoulos
Feb 1, 1986·Immunological Reviews·A RadbruchW Müller
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A RadbruchK Rajewsky
Jan 1, 1988·The Journal of Experimental Medicine·C M SnapperW E Paul
Jul 1, 1988·European Journal of Immunology·S Bergstedt-LindqvistE Severinson
Dec 1, 1988·The Journal of Experimental Medicine·P RothmanF W Alt
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·K OliverE S Vitetta
Oct 25, 1985·Nucleic Acids Research·K C Reed, D A Mann
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·H Aviv, P Leder
Sep 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·P S Thomas
Jul 1, 1983·Analytical Biochemistry·A P Feinberg, B Vogelstein
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·R NoelleE S Vitetta
Dec 1, 1984·The Journal of Experimental Medicine·J E LaytonP H Krammer
Apr 1, 1984·Cell·A Shimizu, T Honjo

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Citations

May 6, 1999·European Journal of Immunology·M A ShermanM A Brown
Jul 1, 1996·Somatic Cell and Molecular Genetics·M LinM D Scharff
Jan 1, 1991·Immunologic Research·Y C LinJ Stavnezer
Nov 13, 2008·Immunologic Research·Laurence U Buxbaum
Jul 1, 1991·Molecular Immunology·M MililiC Schiff
Apr 1, 1993·Molecular Immunology·S Roman-RomanF Triebel
Dec 1, 1989·Current Opinion in Immunology·A Kelso
Apr 1, 1989·Current Opinion in Immunology·G DelespesseC Heusser
Jun 1, 1991·Current Opinion in Immunology·C L Schultz, R L Coffman
Nov 5, 2002·Immunology Letters·Rachel L RoperRichard P Phipps
Sep 29, 1999·Biochimica Et Biophysica Acta·M N McCall, P D Hodgkin
Apr 1, 1996·Current Opinion in Immunology·J Stavnezer
Feb 28, 2009·Nature Reviews. Immunology·Philippa MarrackMichael W Munks
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D A LebmanF D Lee
Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S D ThompsonJ L Hurwitz
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S Gerondakis
Feb 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M Nolan-WillardP Tucker
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·H Leung, N Maizels
Jul 1, 1993·The Journal of Experimental Medicine·Y Wakatsuki, W Strober
Oct 23, 1998·The Journal of Experimental Medicine·J P ManisF W Alt
Jul 1, 1991·British Journal of Haematology·R E Callard
Jul 1, 1992·Scandinavian Journal of Immunology·F MotoyoshiT Orii
Jul 1, 1994·Scandinavian Journal of Immunology·R van OmmenH F Savelkoul
Nov 1, 1994·Scandinavian Journal of Immunology·R Van OmmenH F Savelkoul
Dec 1, 1995·Immunological Reviews·M KopfF Brombacher
Jun 1, 1995·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·N KuwabaraT Orii
Jun 7, 2006·Biological & Pharmaceutical Bulletin·Shunsuke HidaNaohito Ohno
Nov 9, 2012·International Journal of Biological Sciences·Mercedes Rincon, Charles G Irvin
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·C C Chu, W E Paul
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Taro MutoTasuku Honjo

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