May 8, 2007

Synthesis of glycerol phosphate lipoteichoic acid in Staphylococcus aureus

Proceedings of the National Academy of Sciences of the United States of America
Angelika Gründling, Olaf Schneewind

Abstract

Lipoteichoic acid (LTA), a glycerol phosphate surface polymer, is a component of the envelope of Gram-positive bacteria. However, the molecular basis for its synthesis or function is not known. Here we report that Staphylococcus aureus LtaS synthesizes glycerol phosphate LTA. Construction of a mutant S. aureus strain with inducible ltaS expression revealed that LTA synthesis is required for bacterial growth and cell division. An ltaS homologue of Bacillus subtilis restored LTA synthesis and the growth of ltaS mutant staphylococci. Thus, LtaS inhibition can be used as a target to treat human infections caused by antibiotic-resistant S. aureus or other bacterial pathogens.

  • References52
  • Citations141

Mentioned in this Paper

Gram-Positive Bacteria
Bacterial Proteins
Glycerin
Alkalescens-Dispar Group
Cell Division
Thylacodes aureus
Phosphate Measurement
Etiology
Styrax aureus
Bacillus subtilis

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