Synthesis of highly controlled carbohydrate-polymer based hybrid structures by combining heparin fragments and sialic acid derivatives, and solid phase polymer synthesis

Chemical Communications : Chem Comm
Mischa BaierLaura Hartmann

Abstract

Heparin is a polymeric carbohydrate with a variety of biomedical applications that is particularly challenging from a synthetic point of view. Here, we present the synthesis of carbohydrate-polymer based hybrid structures by combining defined heparin fragments with monodisperse, sequence-controlled glycooligo(amidoamines) suitable as glycan mimetic model compounds of heparin as demonstrated by STD-NMR binding studies with viral capsids.

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Citations

Feb 28, 2020·Journal of the American Chemical Society·Laura Soria-MartinezMario Schelhaas

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Methods Mentioned

BETA
NMR

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