Synthesis of Highly Substituted Pyridines through Copper-Catalyzed Condensation of Oximes and α,β-Unsaturated Imines

Angewandte Chemie
Wei Wen TanNaohiko Yoshikai

Abstract

A copper-catalyzed condensation reaction of oxime acetates and α,β-unsaturated ketimines to give pyridine derivatives is reported. The reaction features mild conditions, high functional-group compatibility, and high regioselectivity with respect to unsymmetrical oxime acetates, thus allowing the preparation of a wide range of polysubstituted pyridines, many of which are not readily accessible by conventional condensation methods.

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Citations

Dec 7, 2017·Organic & Biomolecular Chemistry·Yujia XiaGuo-Jun Deng
Apr 27, 2018·Chemistry, an Asian Journal·Da Seul LeeEun Jin Cho
May 29, 2018·Organic & Biomolecular Chemistry·Mi-Na ZhaoZheng-Hui Guan
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Nov 15, 2018·Organic & Biomolecular Chemistry·Qinghe GaoJixia Zhang
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Apr 2, 2019·Chemical Communications : Chem Comm·Zhiping YinXiao-Feng Wu
Jul 31, 2019·Organic & Biomolecular Chemistry·Jing-Wen ZhangDan-Yun Chen
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Jan 27, 2019·Chemical Communications : Chem Comm·Panpan WangZhuangzhi Shi
Feb 18, 2021·The Journal of Organic Chemistry·Yuxin DingYongmin Ma
Aug 19, 2021·Organic Letters·Kai WeiHongbin Zhang
Dec 4, 2019·Organic Letters·Peiqi ZhouHuanfeng Jiang
Dec 26, 2019·The Journal of Organic Chemistry·Meher PrakashSampak Samanta
Sep 1, 2021·The Journal of Organic Chemistry·Chaolumen BaiYong-Sheng Bao
Sep 10, 2021·Organic & Biomolecular Chemistry·Dmitrii A Shabalin

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