Synthesis of Hindered α-Amino Carbonyls: Copper-Catalyzed Radical Addition with Nitroso Compounds

Journal of the American Chemical Society
David J FisherJavier Read de Alaniz

Abstract

The synthesis of sterically hindered anilines has been a significant challenge in organic chemistry. Here we report a Cu-catalyzed radical addition with in situ-generated nitroso compounds to prepare sterically hindered amines directly from readily available materials. The transformation is conducted at room temperature, uses abundant copper salts, and is tolerant of a range of functional groups.

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Citations

Feb 10, 2016·Journal of the American Chemical Society·Keisuke TokumasuTakashi Ohshima
May 10, 2016·Journal of the American Chemical Society·Xiaohong ChenJustin T Mohr
Dec 30, 2015·Chemistry : a European Journal·Rai-Shung LiuPrakash D Jadhav
Feb 6, 2016·Organic & Biomolecular Chemistry·A H St AmantJ Read de Alaniz
Jan 27, 2016·Chemical Communications : Chem Comm·Isai RamakrishnaMahiuddin Baidya
Jul 1, 2016·European Journal of Organic Chemistry·Simon B LangJon A Tunge
Feb 7, 2020·ChemistryOpen·Anna FantinatiClaudio Trapella
Oct 24, 2020·Chemical Communications : Chem Comm·Yang GaoXiao-Qiang Hu
Dec 5, 2020·Chemistry : a European Journal·Satoshi MizutaTakeshi Ishikawa
Nov 15, 2020·Chemical Communications : Chem Comm·Anisha PurkaitChandan K Jana
Sep 6, 2019·Organic Letters·Takuto MorisawaYohei Shimizu
Nov 3, 2017·Journal of the American Chemical Society·Samuel N GockelKami L Hull
Apr 14, 2017·Organic Letters·Angela van der WerfNicklas Selander
Jan 31, 2019·Journal of the American Chemical Society·Zhe ZhouLászló Kürti

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