Synthesis of human des-tryptophan-1,norleucine-12-minigastrin-II and its biological activities

FEBS Letters
E WünschJ P Bali

Abstract

A human minigastrin-II analog was prepared by conventional methods in solution using N-benzyloxycarbonyltyrosine O-sulfate as starting material in the synthetic route. Upon removal of the acid-labile protecting groups and purification by preparative reversed-phase chromatography the sulfated gastrin peptide was obtained in satisfactory overall yields as homogeneous material. It was found to be about twice as active as the non-sulfated form in stimulating gastric acid secretion and to exhibit a 10-fold higher affinity to gastrin receptors of purified parietal cells.

References

Jan 1, 1967·Journal of the Chemical Society. Perkin Transactions 1·J BeachamR C Sheppard

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Citations

Jan 1, 1997·Journal of Peptide Science : an Official Publication of the European Peptide Society·L Moroder
Oct 19, 2001·The Journal of Peptide Research : Official Journal of the American Peptide Society·S I AhmedS Lovas
Jun 9, 2016·Biochimica Et Biophysica Acta·Dmytro S RadchenkoSergii Afonin

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