Synthesis of Imidazole-Based Medicinal Molecules Utilizing the van Leusen Imidazole Synthesis

Pharmaceuticals
Xunan ZhengDawei Zhang

Abstract

Imidazole and its derivatives are one of the most vital and universal heterocycles in medicinal chemistry. Owing to their special structural features, these compounds exhibit a widespread spectrum of significant pharmacological or biological activities, and are widely researched and applied by pharmaceutical companies for drug discovery. The van Leusen reaction based on tosylmethylisocyanides (TosMICs) is one of the most appropriate strategies to synthetize imidazole-based medicinal molecules, which has been increasingly developed on account of its advantages. In this review, we summarize the recent developments of the chemical synthesis and bioactivity of imidazole-containing medicinal small molecules, utilizing the van Leusen imidazole synthesis from 1977.

References

Oct 1, 1989·British Journal of Cancer·D PectasidesA Athanassiou
Apr 1, 1981·British Journal of Cancer·P D JosephyL D Skarsgard
Apr 1, 1996·The Journal of Antimicrobial Chemotherapy·A J Carrilo-MuñozJ Torres
May 18, 2000·The Journal of Organic Chemistry·J SiskoM A Olsen
Mar 4, 2008·Current Opinion in Chemical Biology·Irini Akritopoulou-Zanze
Mar 4, 2011·The European Journal of Neuroscience·Mouhammad Motawaj, Jean-Michel Arrang
Jan 28, 2012·European Journal of Medicinal Chemistry·Loredana SalernoValeria Sorrenti
Mar 19, 2013·Tetrahedron Letters·Fabio De Moliner, Christopher Hulme
Jun 7, 2013·Medicinal Research Reviews·Ling ZhangCheng-He Zhou
Jan 13, 2011·ACS Medicinal Chemistry Letters·Ulrike E HilleRolf W Hartmann
Aug 4, 2015·European Journal of Organic Chemistry·J Armando Lujan-MontelongoFraser F Fleming
May 6, 2017·Scientific Reports·Adam S HogendorfAndrzej J Bojarski
Feb 20, 2018·ACS Medicinal Chemistry Letters·Michael G BrantDonald F Weaver
Mar 16, 2018·European Journal of Medicinal Chemistry·Yi-Lei FanLian-Shun Feng
Jun 30, 2019·Organic & Biomolecular Chemistry·Arun Divakar Mathiyazhagan, Gopinathan Anilkumar

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Citations

Apr 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xunan ZhengDawei Zhang
Nov 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Renzo Rossi, Maurizio Ciofalo
Nov 11, 2020·Chemistry : a European Journal·Hyunho KimEunsung Lee
May 1, 2021·Biomolecules·Alex R MedeirosAdriano D Andricopulo
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Theresa SchmidtRené Csuk
Jul 24, 2021·Journal of Pharmacological Sciences·Titilayo O JohnsonOluyomi Stephen Adeyemi
Jul 25, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sergii DemchenkoAnatolii Demchenko
Oct 24, 2020·Current Topics in Medicinal Chemistry·Ana I MatesanzAdoración G Quiroga
Aug 19, 2021·The Journal of Organic Chemistry·Christian SchumacherCarsten Bolm

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