Synthesis of indirubin-N'-glycosides and their anti-proliferative activity against human cancer cell lines

Bioorganic & Medicinal Chemistry
Stefanie LibnowPeter Langer

Abstract

The first indirubin-N'-glycosides were prepared based on reactions of isatin-N'-glycosides with indoxyls. The products show a significant anti-proliferative activity against various human cancer cell lines. Good results were observed for an indirubin-N'-mannoside which was shown to have medium to high anti-proliferative activity against all investigated cell lines. The highest activities and selectivities against the MCF-7 breast cancer cell line were observed for indirubin-N'-rhamnosides.

Citations

Apr 14, 2011·Chemical Communications : Chem Comm·Kentaro OkumaYoshinobu Yokomori
Oct 31, 2008·Organic & Biomolecular Chemistry·Katrin Marie DrillerPeter Langer
May 16, 2013·Organic & Biomolecular Chemistry·Friedrich ErbenPeter Langer
Apr 13, 2013·Chemical Communications : Chem Comm·Yogesh Goriya, Chepuri V Ramana
Jan 5, 2013·Organic & Biomolecular Chemistry·Dennis KleeblattPeter Langer
Jul 18, 2014·Drug Discoveries & Therapeutics·Pengzhan LiGuisen Zhao
Mar 15, 2019·International Journal of Molecular Sciences·Marwa Y SoltanJürgen Eberle
Aug 21, 2019·Chemical Communications : Chem Comm·Lingmei GuoYong Wu
May 14, 2020·Organic Letters·Boris LetribotSamir Messaoudi
Nov 27, 2014·Journal of Natural Products·Wei GuChun-Lin Long

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.