Synthesis of Indolizine Derivatives by Pd-Catalyzed Oxidative Carbonylation

Organic Letters
Tongyu Xu, Howard Alper

Abstract

An efficient synthesis of indolizine derivatives by palladium-catalyzed oxidative carbonylation of propargylic pyridines has been developed. The reaction can be conducted at room temperature and under 3 bar of CO in the presence of Pd2(dba)3 or Pd/C. The catalyst Pd/C could be easily removed from the reaction and recycled.

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Citations

Apr 2, 2016·The Journal of Organic Chemistry·Xiangdong LiYuanhong Liu
Jul 6, 2016·The Journal of Organic Chemistry·Basuli Suchand, Gedu Satyanarayana
Jul 12, 2016·Organic & Biomolecular Chemistry·Bartłomiej SadowskiDaniel T Gryko

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