Synthesis of Indolizines from Pyridinium Salts and Ethyl Bromodifluoroacetate.

Organic Letters
Xiaoya HouGuangwei Wang

Abstract

Here we present a novel annulation of pyridinium salts with BrCF2CO2Et to access the indolizine derivatives with high efficiency. The α substitution of pyridine plays a key role in determining the reaction pathways. Various types of indolizines can be conveniently accessed from easily available pyridinium salts under mild and simple reaction conditions.

References

Sep 14, 2006·Journal of the American Chemical Society·Ilya V Seregin, Vladimir Gevorgyan
Nov 3, 2006·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Lise-Lotte GundersenSolomon Teklu
Sep 29, 2007·Science·Klaus MüllerFrançois Diederich
Feb 6, 2008·Natural Product Reports·Joseph P Michael
Jun 16, 2010·Organic Letters·Dmitri ChernyakVladimir Gevorgyan
Mar 19, 2011·Journal of Medicinal Chemistry·Nicholas A Meanwell
Jan 1, 2010·Green Chemistry : an International Journal and Green Chemistry Resource : GC·Alison R Hardin Narayan, Richmond Sarpong
Mar 6, 2013·Angewandte Chemie·Qianghui ZhouPhil S Baran
Mar 24, 2015·Journal of Medicinal Chemistry·Peiling ChenDavid H Drewry
Jul 12, 2016·Organic & Biomolecular Chemistry·Bartłomiej SadowskiDaniel T Gryko
Jun 23, 2018·Chemical Communications : Chem Comm·Xingxing MaQiuling Song
Mar 1, 2019·The Journal of Organic Chemistry·Yanyan YangMinjie Guo
Jun 25, 2019·Chemical Communications : Chem Comm·Xiaoxia YuQiuling Song

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