Synthesis of Iron Nanometallic Glasses and Their Application in Cancer Therapy by a Localized Fenton Reaction

Angewandte Chemie
Chen ZhangJianlin Shi

Abstract

Metallic glasses and cancer theranostics are emerging fields that do not seem to be related to each other. Herein, we report the facile synthesis of amorphous iron nanoparticles (AFeNPs) and their superior physicochemical properties compared to their crystalline counterpart, iron nanocrystals (FeNCs). The AFeNPs can be used for cancer theranostics by inducing a Fenton reaction in the tumor by taking advantage of the mild acidity and the overproduced H2 O2 in a tumor microenvironment: Ionization of the AFeNPs enables on-demand ferrous ion release in the tumor, and subsequent H2 O2 disproportionation leads to efficient (.)OH generation. The endogenous stimuli-responsive (.)OH generation in the presence AFeNPs enables a highly specific cancer therapy without the need for external energy input.

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Citations

Jan 10, 2017·Nature Nanotechnology·Chen ZhangJianlin Shi
Apr 21, 2017·Chemical Communications : Chem Comm·Vu Thanh CongSang-Woo Joo
Jun 2, 2017·Advanced Healthcare Materials·Vimalkumar BalasubramanianHélder A Santos
Feb 28, 2017·Macromolecular Rapid Communications·Zhengyu DengShiyong Liu
Mar 25, 2018·Advanced Materials·Hyek Jin KwonTaeghwan Hyeon
Jan 23, 2018·Advanced Materials·Zheyu ShenXiaoyuan Chen
Dec 17, 2017·Journal of Labelled Compounds & Radiopharmaceuticals·Anping JiMinghua Du
Dec 29, 2017·Advanced Healthcare Materials·Liying WangJianlin Shi
Oct 11, 2016·Chemical Society Reviews·Zijian ZhouXiaoyuan Chen
Jun 26, 2018·Advanced Healthcare Materials·Bowen YangJianlin Shi
Jul 7, 2018·Chemical Communications : Chem Comm·Lu-Ying DuanJian-Hui Jiang
Aug 23, 2018·Advanced Materials·Dokyoon KimTaeghwan Hyeon
Nov 15, 2018·Physical Chemistry Chemical Physics : PCCP·Vuk UskokovićDragan P Uskoković
Dec 28, 2018·Advanced Materials·Hui WangXinghua Shi
Mar 14, 2019·Nanoscale·Hadi Ranji-BurachalooGreg G Qiao
May 16, 2019·Chemical Society Reviews·Wei TangXiaoyuan Chen
Jul 4, 2019·Advanced Healthcare Materials·Gaoxin ZhouQianjun He
Jul 23, 2019·Advanced Materials·Bowen YangJianlin Shi
Oct 9, 2019·Advanced Materials·Chen LiangXiaochen Dong

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