PMID: 6160026Jan 1, 1980Paper

Synthesis of methotrexate polyglutamates by bone marrow cells from patients with leukemia and lymphoma

Developmental Pharmacology and Therapeutics
A WitteM J Vuchich

Abstract

Bone marrow cells from children with lymphoblastic leukemia, myeloblastic leukemia and non-Hodgkin's lymphoma were incubated with tritium-labelled methotrexate in short-term cultures. Cells obtained both during disease activity as well as during remission synthesized large quantities of methotrexate polyglutamates. Synthesis was time- and dose-dependent and occurred with concentrations of methotrexate regularly achieved during conventional treatment with this drug.

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