Synthesis of monophasic Ag doped hydroxyapatite and evaluation of antibacterial activity

Materials Science & Engineering. C, Materials for Biological Applications
Madeeha RiazAbdul Malik

Abstract

The present study aims to synthesized biomaterial that has antibacterial properties. Currently the surgical implants associated infections are a major cause of implant failure. Synthesis of silver doped hydroxyapatite as an antibacterial agent has potential importance to overcome post-surgical infections in a variety of clinical applications. Five silver doped hydroxyapatite Ca10-xAgx(PO4)6(OH)2 (x = 0, 0.1, 0.3, 0.5, 0.7 M) samples were synthesized by precipitation method and sintered at 900 °C to obtain well crystallized structure. No minor phase developed with silver addition, hexagonal hydroxyapatite (JCPDS# 09-432) was the single phase identified in all silver doped hydroxyapatite samples. The lattice parameter a and c changed with increase in silver concentration. The results of in vitro bioactivity revealed the bone bonding ability of silver doped hydroxyapatite samples. The antibacterial test showed that silver doped hydroxyapatite was sensitive to Staphylococcus aureus bacteria. Addition of silver significantly (P < 0.005) increased the antibacterial activity.

Citations

Aug 25, 2019·Nanomaterials·Ecaterina AndronescuBogdan Stefan Vasile
Sep 22, 2020·Dose-response : a Publication of International Hormesis Society·Pamela Nair Silva-Holguín, Simón Yobanny Reyes-López
Dec 2, 2020·Colloids and Surfaces. B, Biointerfaces·Cleibson Oliveira de LimaMaria Gardênia Fonseca
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Jingwen HouBangshang Zhu
Feb 23, 2021·Bioactive Materials·Erlin ZhangGaowu Qin
Oct 9, 2019·ACS Applied Materials & Interfaces·Alexander SobolevKonstantin Borodianskiy
Jan 13, 2022·ACS Applied Materials & Interfaces·Koichiro HayashiKunio Ishikawa
Jan 19, 2022·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Diana Julaidy PattyYusril Yusuf
Feb 3, 2022·Journal of Biomaterials Science. Polymer Edition·Diana Julaidy PattyYusril Yusuf

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