Synthesis of multisubstituted quinolines from Baylis-Hillman adducts obtained from substituted 2-chloronicotinaldehydes and their antimicrobial activity

Bioorganic & Medicinal Chemistry
P NarenderV Jayathirtha Rao

Abstract

Baylis-Hillman acetates were synthesized from substituted 2-chloronicotinaldehydes and were conveniently transformed into multisubstituted quinolines and cyclopenta[g]quinolines on reaction with nitroethane or ethyl cyanoacetate via a successive S(N)2'-S(N)Ar elimination strategy. Thus, synthesized quinolines were evaluated for antimicrobial activity and found having substantial antibacterial and antifungal activity.

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Citations

Nov 28, 2013·European Journal of Medicinal Chemistry·Thatikonda Narendar ReddyVaidya Jayathirtha Rao
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