Synthesis of N-aryl-3-(indol-3-yl)propanamides and their immunosuppressive activities

Bioorganic & Medicinal Chemistry Letters
Francis GiraudMuriel Duflos

Abstract

N-aryl-3-(indol-3-yl)propanamides were synthesized and their immunosuppressive activities were evaluated. This study highlighted the promising potency of 3-[1-(4-chlorobenzyl)-1H-indol-3-yl]-N-(4-nitrophenyl)propanamide 15 which exhibited a significant inhibitory activity on murine splenocytes proliferation assay in vitro and on mice delayed-type hypersensitivity (DTH) assay in vivo.

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Citations

Sep 20, 2015·Ultrasonics Sonochemistry·Ali RamazaniSang Woo Joo

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